Wolff–Parkinson–White syndrome (WPWS) is a disorder due to a specific type of problem with the electrical system of the heart which has resulted in symptoms.[2][3] About 40% of people with the electrical problem never develop symptoms.[5] Symptoms can include an abnormally fast heartbeat, palpitations, shortness of breath, lightheadedness, or syncope.[1] Rarely cardiac arrest may occur.[1] The most common type of irregular heartbeat that occurs is known as paroxysmal supraventricular tachycardia.[1]

The cause of WPW is typically unknown.[2] A small number of cases are due to a mutation of the PRKAG2 gene which may be inherited from a person's parents in an autosomal dominant fashion.[2] The underlying mechanism involves an accessory electrical conduction pathway between the atria and the ventricles.[1] It is associated with other conditions such as Ebstein anomaly and hypokalemic periodic paralysis.[1] Diagnosis is typically when an electrocardiogram (ECG) show a short PR interval and a delta wave.[3] It is a type of pre-excitation syndromes.[3]

WPW syndrome is treated with either medications or radiofrequency catheter ablation.[4] It affects between 0.1 and 0.3% in the population.[1] The risk of death in those without symptoms is about 0.5% per year in children and 0.1% per year in adults.[5] In those without symptoms ongoing observation may be reasonable.[5] In those with WPW complicated by atrial fibrillation, cardioversion or the medication procainamide may be used.[6] The condition is named after Louis Wolff, John Parkinson, and Paul Dudley White who described the ECG findings in 1930.[3]

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